4-Nitrobenzoyl-1,3-dihydroimidazol-2-one → 4-Aminobenzoyl-1,3-dihydroimidazol-2-one

HRID 1348952노트

반응식

HRID 1348952 반응식
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([C:8]([N:10]2[CH:14]=[CH:13][NH:12][C:11]2=[O:15])=[O:9])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:17]=[CH:16][C:7]([C:8]([N:10]2[CH:14]=[CH:13][NH:12][C:11]2=[O:15])=[O:9])=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 210928284-Nitrobenzoyl-1,3-dihydroimidazol-2-one

생성물 1

HCID 210928274-Aminobenzoyl-1,3-dihydroimidazol-2-one수율 98%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1b (200 mg, 0.86 mmol) in 20 mL MeOH was hydrogenated over 10% Pd/C (40 mg) at 50 psi H2. The reaction mixture was filtered through a plug of Celite®, washed with MeOH and concentrated on a rotary evaporator to give 168 mg (98% yield) of 4-aminobenzoyl-1,3-dihydroimidazol-2-one 1c. MS found: (M+H)+=204.

후처리

  1. filtrationThe reaction mixture was filtered through a plug of Celite®
  2. washwashed with MeOH
  3. concentrationconcentrated on a rotary evaporator

출처 및 근거

ORD 기록
ord-1ac651baa03c4e54aa987366e32b7de2
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07211671B2

반응 노트

불러오는 중…