5-Methyl-4-phenyl-1,3-thiazole-2-sulfonyl chloride → HCID 21092807, 화합물

반응식

Cl.Cl.[CH2:3]([O:5][C:6](=[O:12])[CH2:7][NH:8][CH2:9][CH2:10][NH2:11])[CH3:4].[CH3:13][C:14]1[S:18][C:17]([S:19](Cl)(=[O:21])=[O:20])=[N:16][C:15]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:3]([O:5][C:6](=[O:12])[CH2:7][NH:8][CH2:9][CH2:10][NH:11][S:19]([C:17]1[S:18][C:14]([CH3:13])=[C:15]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:16]=1)(=[O:20])=[O:21])[CH3:4]

참가 물질

반응물 2

HCID 210927555-Methyl-4-phenyl-1,3-thiazole-2-sulfonyl chloride

HCID 74889816N-beta-Aminoethyl-gly-oet 2hcl

생성물 1

HCID 21092807HCID 21092807, 화합물

실험 절차

The title compound was synthesized by the reaction of N-(2-aminoethyl)-glycine ethyl ester 2HCl with 5-methyl-4-phenyl-thiazole-2-sulfonyl chloride as per the procedure of example 1. 1H NMR (500 MHz; DMSO-d6) δ 7.68 (d, 2H), 7.51 (t, 2H), 7.44 (t, 1H), 4.05 (q, 2H), 3.26 (s, 2H), 3.10 (t, 2H), 2.64 (s, 3H), 2.63 (t, 2H), 1.16 (t, 3H).

출처 및 근거

ORD 기록: ord-2d0c05b073f64b17b69ee55bea6338ab
출처 데이터셋: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07211668B2

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