참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 4-Isothiocyanatobenzoic acid | HCID 242946 | — |
| 반응물 | 4-(3-Amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamide | HCID 17755838 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Benzoic Acid | HCID 243 | — |
반응 단계
To {4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 4-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h. and concentrated the solvent and purified on silica gel to yield 4-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728010B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-0db3fcedba7b4eb1b027317ca6693d87 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
