2,1,3-Benzothiadiazol-4-amine → (2S)-N2-(2,1,3-benzothiadiazol-4-yl)-N1-(3,5-dichlorophenyl)-4-oxo-1,2-pyrrolidinedicarboxamide

HRID 1349053

반응식

HRID 1349053 반응식
C(O[C:6]([N:8]1[CH2:15][C:14](=[O:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[Cl:17][C:18]1[CH:23]=[C:22]([N:24]=C=O)[CH:21]=[C:20]([Cl:27])[CH:19]=1.[N:28]1[S:29][N:30]=[C:31]2[C:36]([NH2:37])=[CH:35][CH:34]=[CH:33][C:32]=12>>[N:28]1[S:29][N:30]=[C:31]2[C:36]([NH:37][C:10]([C@@H:9]3[CH2:13][C:14](=[O:16])[CH2:15][N:8]3[C:6]([NH:24][C:22]3[CH:23]=[C:18]([Cl:17])[CH:19]=[C:20]([Cl:27])[CH:21]=3)=[O:7])=[O:12])=[CH:35][CH:34]=[CH:33][C:32]=12

참가 물질

4

반응물 3

HCID 698452,1,3-Benzothiadiazol-4-amineHCID 944603,5-Dichlorophenyl isocyanateHCID 11593804(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid

생성물 1

HCID 69247735(2S)-N2-(2,1,3-benzothiadiazol-4-yl)-N1-(3,5-dichlorophenyl)-4-oxo-1,2-pyrrolidinedicarboxamide

실험 절차

Following the general method as outlined in Example 22, starting from l-(tert-butoxy-carbonyl)-4-oxoproline, 1,3-dichloro-5-isocyanatobenzene, and 2,1,3-benzothiadiazol-4-amine the title compound was obtained in 47% purity by LC/MS. MS(ESI+): m/z=450.6.

출처 및 근거

ORD 기록
ord-d2207107f7364d6d85e12ceafbe4a1ff
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07211601B2

연결된 노트

불러오는 중…