O-Phenylenediamine → (3EZ,5S)-5-(1H-benzimidazol-2-yl)-1-(diphenylacetyl)-3-pyrrolidinone O-allyloxime

HRID 1349074노트

반응식

HRID 1349074 반응식
[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([O:13]C(C)(C)C)=O)[C@H:8]([C:18](O)=O)[CH2:7]1)[CH:2]=[CH2:3].[C:21]1([CH:27]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)C(Cl)=O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[C:37]1([NH2:44])[C:38]([NH2:43])=[CH:39][CH:40]=[CH:41][CH:42]=1>>[CH2:1]([O:4][N:5]=[C:6]1[CH2:7][C@@H:8]([C:18]2[NH:44][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=3[N:43]=2)[N:9]([C:11](=[O:13])[CH:27]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:10]1)[CH:2]=[CH2:3]

참가 물질

4

반응물 3

HCID 7243O-PhenylenediamineHCID 746372,2-Diphenylacetyl chlorideHCID 58714562(2S,4EZ)-4-[(allyloxy)imino)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

생성물 1

HCID 131725449(3EZ,5S)-5-(1H-benzimidazol-2-yl)-1-(diphenylacetyl)-3-pyrrolidinone O-allyloxime

실험 절차

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyloxy)-imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 1,2-benzenediamine the title compound was obtained in 63% purity by LC/MS. MS(ESI+): m/z=451.4.

출처 및 근거

ORD 기록
ord-7205e2ae2f9549d9b97bc07cfa8766d5
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07211601B2

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