2,1,3-Benzothiadiazol-4-amine → (2S,4EZ)-N-(2,1,3-benzothiadiazol-4-yl)-4-[(benzyloxy)imino]-1-(4-cyanobenzoyl)-2-pyrrolidinecarboxamide

HRID 1349103

반응식

HRID 1349103 반응식
[CH2:1]([O:8][N:9]=[C:10]1[CH2:14][N:13]([C:15]([O:17]C(C)(C)C)=O)[C@H:12]([C:22]([OH:24])=O)[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]([C:27]1[CH:35]=[CH:34][C:30](C(Cl)=O)=[CH:29][CH:28]=1)#[N:26].[N:36]1[S:37][N:38]=[C:39]2[C:44]([NH2:45])=[CH:43][CH:42]=[CH:41][C:40]=12>>[N:36]1[S:37][N:38]=[C:39]2[C:44]([NH:45][C:22]([C@@H:12]3[CH2:11][C:10](=[N:9][O:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH2:14][N:13]3[C:15](=[O:17])[C:30]3[CH:29]=[CH:28][C:27]([C:25]#[N:26])=[CH:35][CH:34]=3)=[O:24])=[CH:43][CH:42]=[CH:41][C:40]=12

참가 물질

4

반응물 3

HCID 698452,1,3-Benzothiadiazol-4-amineHCID 801724-Cyanobenzoyl chlorideHCID 131725420(2S,4EZ)-4[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

생성물 1

HCID 131725477(2S,4EZ)-N-(2,1,3-benzothiadiazol-4-yl)-4-[(benzyloxy)imino]-1-(4-cyanobenzoyl)-2-pyrrolidinecarboxamide

실험 절차

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 4-cyanobenzoyl chloride, and 2,1,3-benzothiadiazol-4-amine the title compound was obtained in 55% purity by LC/MS. MS(ESI+): m/z=497.4.

출처 및 근거

ORD 기록
ord-6cf28f81cf36406b94f44969a4210e2c
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07211601B2

연결된 노트

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