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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1349289생성일: 2026년 10월 26일

(1S)-2-amino-1-phenylethan-1-ol → (2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-1-[(2'-methoxy[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide

https://huagongshe.com/reaction/1349289

반응식

참여 물질

역할이름HCID투입량
반응물(1S)-2-amino-1-phenylethan-1-olHCID 643217—
반응물2'-Methoxy-biphenyl-4-carboxylic acidHCID 2759548—
반응물(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acidHCID 58714586—
생성물(2S,4EZ)-N-[(2S)-2-hydroxy-2-phenylethyl]-1-[(2'-methoxy[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamideHCID 131726402—

반응 단계

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-methoxy[1,1′-biphenyl]-4-carboxylic acid, and (1S)-2-amino-1-phenylethanol, the title compound was obtained in 90% purity by HPLC. MS(ESI+): m/z=488.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07211601B2
출처 데이터셋uspto-grants-2007_05
ORD IDord-e1ed1b4c37c14cd2866843e2e24052b9
출처 메모uspto-grants-2007_05