Methyl 9-benzyloxy-2-(3-chlorobenzyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate → Methyl 2-(3-chlorobenzyl)-1,8-dioxo-9-hydroxy-1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine-7-carboxylate
반응식
C(OC1C(=O)C(Br)=CN2CCN(CC3C=CC=C(Cl)C=3)C(=O)C=12)C1C=CC=CC=1.C([O:37][C:38]1[C:39](=[O:61])[C:40]([C:57]([O:59][CH3:60])=[O:58])=[CH:41][N:42]2[CH2:47][CH2:46][N:45]([CH2:48][C:49]3[CH:54]=[CH:53][CH:52]=[C:51]([Cl:55])[CH:50]=3)[C:44](=[O:56])[C:43]=12)C1C=CC=CC=1>>[Cl:55][C:51]1[CH:50]=[C:49]([CH:54]=[CH:53][CH:52]=1)[CH2:48][N:45]1[CH2:46][CH2:47][N:42]2[CH:41]=[C:40]([C:57]([O:59][CH3:60])=[O:58])[C:39](=[O:61])[C:38]([OH:37])=[C:43]2[C:44]1=[O:56]참가 물질
반응물 2
생성물 1
실험 절차
By subjecting 9-benzyloxy-7-bromo-2-(3-chlorobenzyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (600 mg) produced by the same method as in Example 249, Step 1 to a reaction operation similar to that in Example 161, Step 3, a mixture of methyl 9-benzyloxy-2-(3-chlorobenzyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate and methyl 2-(3-chlorobenzyl)-1,8-dioxo-9-hydroxy-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate was obtained (13 mg). This mixture was dissolved in dimethylformamide (17 ml) and treated with benzyl bromide (1.36 g) and potassium carbonate (1.75 g) and purified by silica gel column chromatography (ethyl acetate-chloroform:methanol=10:1) to give methyl 9-benzyloxy-2-(3-chlorobenzyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate (480 mg).
후처리
- customproduced by the same method as in Example 249, Step 1 to a reaction operation similar to that in Example 161, Step 3
출처 및 근거
- ORD 기록
- ord-35beb3b9099b4af6a8333c8e64adfadd
- 출처 데이터셋
- uspto-grants-2007_05
- 특허 번호
- US07211572B2
반응 노트
불러오는 중…