1-Carbomethoxy-2-benzylamino-3,4-dihydronaphthalene → HCID 58646756, 화합물

HRID 1350193

반응식

HRID 1350193 반응식
[C:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]=1[NH:15]CC1C=CC=CC=1)([O:3][CH3:4])=[O:2]>CO.[Pd]>[C:1]([C@@H:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C@@H:6]1[NH2:15])([O:3][CH3:4])=[O:2]

참가 물질

4

반응물 1

HCID 210946731-Carbomethoxy-2-benzylamino-3,4-dihydronaphthalene

생성물 1

HCID 58646756HCID 58646756, 화합물수율 15.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a suspension of 1-carbomethoxy-2-benzylamino-3,4-dihydronaphthalene (1.46 g) in methanol (30 mL) at room temperature, was added 10% palladium on carbon (200 mg). The resulting mixture was shaken under a hydrogen atmosphere at 40 psi for 3 d using a Parr apparatus. The catalyst was filtered, and the filtrate was evaporated under vacuum to obtain crude product. The crude product was purified by reverse phase preparative HPLC to obtain predominantly cis 1-carbomethoxy-2-amino-1,2,3,4-tetrahydronaphthalene (160 mg) as a cis-trans mixture (10:1).

후처리

  1. filtrationThe catalyst was filtered
  2. customthe filtrate was evaporated under vacuum
  3. customto obtain crude product
  4. customThe crude product was purified by reverse phase preparative HPLC

출처 및 근거

ORD 기록
ord-5df5577a07544c31ad34fcc1d73bbb91
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214704B2

연결된 노트

불러오는 중…