N,N-dimethyl-5-nitropyridin-2-amine → N2,N2-dimethylpyridine-2,5-diamine

HRID 13507

반응식

HRID 13507 반응식
[CH3:1][N:2]([CH3:12])[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][N:4]=1>[Pd].C(O)C>[CH3:1][N:2]([CH3:12])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][N:4]=1

참가 물질

4

반응물 1

HCID 75707N,N-dimethyl-5-nitropyridin-2-amine

생성물 1

HCID 78642N2,N2-dimethylpyridine-2,5-diamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 2-(dimethylamino)-5-nitropyridine (1 eq) and 5% palladium on carbon (0.3 eq) in ethanol was stirred at room temperature and flushed with nitrogen. The reaction vessel was evacuated and purged with hydrogen three times. The reaction mixture was left under an atmosphere of hydrogen overnight. Nitrogen was flushed through the reaction and then the reaction was filtered through a celite pad. The celite pad was washed with excess ethanol before the solvent was removed by evaporation under reduced pressure to afford 2-(dimethylamino)-5-aminopyridine.

후처리

  1. customflushed with nitrogen
  2. customThe reaction vessel was evacuated
  3. custompurged with hydrogen three times
  4. customNitrogen was flushed through the reaction
  5. filtrationthe reaction was filtered through a celite pad
  6. washThe celite pad was washed with excess ethanol before the solvent
  7. customwas removed by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-b3951463aaae402abfa19be9984785d4
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728010B2

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