3-Azido-N-[3-methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-4-methyl-benzamide → 3-[4-(2-Benzoyl-3-methyl-3H-imidazol-4-yl)-[1,2,3]triazol-1-yl]-N-[3-methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-4-methyl-benzamide

HRID 1350709

반응식

HRID 1350709 반응식
[C:1]([C:3]1[N:7]([CH3:8])[C:6]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[N:5][CH:4]=1)#[CH:2].[N:17]([C:20]1[CH:21]=[C:22]([CH:43]=[CH:44][C:45]=1[CH3:46])[C:23]([NH:25][C:26]1[CH:31]=[C:30]([C:32]2([CH3:35])[CH2:34][CH2:33]2)[CH:29]=[C:28]([NH:36][S:37]([CH3:40])(=[O:39])=[O:38])[C:27]=1[O:41][CH3:42])=[O:24])=[N+:18]=[N-:19]>>[C:9]([C:6]1[N:7]([CH3:8])[C:3]([C:1]2[N:19]=[N:18][N:17]([C:20]3[CH:21]=[C:22]([CH:43]=[CH:44][C:45]=3[CH3:46])[C:23]([NH:25][C:26]3[CH:31]=[C:30]([C:32]4([CH3:35])[CH2:33][CH2:34]4)[CH:29]=[C:28]([NH:36][S:37]([CH3:40])(=[O:39])=[O:38])[C:27]=3[O:41][CH3:42])=[O:24])[CH:2]=2)=[CH:4][N:5]=1)(=[O:10])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

3

반응물 2

HCID 210972993-Azido-N-[3-methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-4-methyl-benzamideHCID 21097345(5-Ethynyl-1-methyl-1H-imidazol-2-yl)-phenyl-methanone

생성물 1

HCID 210970743-[4-(2-Benzoyl-3-methyl-3H-imidazol-4-yl)-[1,2,3]triazol-1-yl]-N-[3-methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-4-methyl-benzamide

실험 절차

Example 34 was prepared from (5-ethynyl-1-methyl-1H-imidazol-2-yl)-phenyl-methanone (Example 33) and 3-azido-N-[3-methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-4-methyl-benzamide (Example 33) in the same manner as Example 15. ESI MS m/z 640 [C33H33N7O5S+H]+.

출처 및 근거

ORD 기록
ord-607a66c77c4747e591d9f10cdad8315f
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214802B2

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