Trifluoroacetic acid → [3-Chloro-4-(trifluoromethyl)phenoxy]acetic acid

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[C:17]([F:20])([F:19])[F:18])[O:5][CH2:6][C:7]([O:9]C(C)(C)C)=[O:8].FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[C:17]([F:18])([F:19])[F:20])[O:5][CH2:6][C:7]([OH:9])=[O:8]

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 58640420tert-Butyl [3-chloro-4-(trifluoromethyl)phenoxy]acetate

생성물 1

HCID 21097484[3-Chloro-4-(trifluoromethyl)phenoxy]acetic acid수율 80%

실험 절차

tert-Butyl [3-chloro-4-(trifluoromethyl)phenoxy]acetate (1.2 g, 3.8 mmol) was added trifluoroacetic acid (TFA) (3 ml). The mixture was stirred for 5 hours at ambient temperature. The solvent was removed under reduced pressure to give the residue, which was applied to a recrystallization from hexane-methylene dichloride to furnish 251 mg (80% yield) of the title compound as a brown solid.

후처리

customThe solvent was removed under reduced pressure
customto give the residue, which
customwas applied to a recrystallization from hexane-methylene dichloride

출처 및 근거

ORD 기록: ord-3354943425a34c6ea8199794d0bb8eb7
출처 데이터셋: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07214824B2

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