2,3-Dihydro-5-methoxy-1,1-dimethyl-1H-indene → HCID 23014065, 화합물

HRID 1350853노트

반응식

HRID 1350853 반응식
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH3:13])([CH3:12])[CH2:7][CH2:6]2.ClCCl.B(Br)(Br)Br>ClCCl>[CH3:12][C:8]1([CH3:13])[C:9]2[C:5](=[CH:4][C:3]([OH:2])=[CH:11][CH:10]=2)[CH2:6][CH2:7]1

참가 물질

4

반응물 2

HCID 221522852,3-Dihydro-5-methoxy-1,1-dimethyl-1H-indeneHCID 22277759Boron tribromide dichloromethane

생성물 1

HCID 23014065HCID 23014065, 화합물수율 101.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 5-methoxy-1,1-dimethylindane (941 mg, 5.34 mmol) in anhydrous dichloromethane (20 ml) was added 1.0 M boron tribromide dichloromethane solution (10.7 ml, 10.7 mmol) via a syringe at −78° C. The mixture was warmed to ambient temperature and stirred for 1.5 hours. The mixture was quenched with water (15 ml) and extracted with dichloromethane. The combined solution was washed with brine, dried over sodium sulfate. After filtration to separate solvent and sodium sulfate, the solvent was removed under reduced pressure to give 878 mg of the crude 1,1-dimethylindan-5-ol as a gray solid.

후처리

  1. customThe mixture was quenched with water (15 ml)
  2. extractionextracted with dichloromethane
  3. washThe combined solution was washed with brine
  4. dry with materialdried over sodium sulfate
  5. filtrationAfter filtration
  6. customto separate solvent and sodium sulfate
  7. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-f14d9b846dcc4df29719b9627ab33c71
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214824B2

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