2-(4-Fluorophenyl)acetic acid → N-Cyclopropyl-2-(4-fluorophenyl)acetamide

HRID 1351258노트

반응식

HRID 1351258 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[CH:12]1([NH2:15])[CH2:14][CH2:13]1.ON1C2C=CC=CC=2N=N1.CN(C)CCCN=C=NCC>CN(C)C=O.O>[CH:12]1([NH:15][C:9](=[O:11])[CH2:8][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[CH2:14][CH2:13]1

참가 물질

7

반응물 4

HCID 98372-(4-Fluorophenyl)acetic acidHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 69828CyclopropylamineHCID 757711-Hydroxybenzotriazole

생성물 1

HCID 21098726N-Cyclopropyl-2-(4-fluorophenyl)acetamide수율 74.3%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-fluorophenylacetic acid (4.5 g) and cyclopropylamine (1.7 g) in N,N-dimethylformamide (60 mL) was added 1-Hydroxybenzotriazole (4.4 g), followed by 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide (WSC) hydrochloride (6.2 g) on an ice bath. This solution was stirred for 4.5 hours while gradually warming to room temperature. The reaction solution was poured into water (120 mL) on an ice bath, and the resulting solid was collected by filtration, washed with water, then dried, and the title compound (4.19 g) was obtained as a colorless solid.

후처리

  1. filtrationthe resulting solid was collected by filtration
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-a463893a2c434d32b3da73166255e073
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217723B2

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