Hydrogen chloride-ethyl acetate → [2-(4-Fluoro-3-methoxyphenyl)ethyl]methylamine hydrochloride

HRID 1351263노트

반응식

HRID 1351263 반응식
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[C:13]([O:18][CH3:19])[CH:12]=1)C)(C)(C)C.[ClH:21].C(OCC)(=O)C>C(OCC)(=O)C.C(OCC)C>[ClH:21].[F:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][NH:7][CH3:6])=[CH:12][C:13]=1[O:18][CH3:19]

참가 물질

5

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69413197[2-(4-Fluoro-3-methoxyphenyl)ethyl]methylcarbamic acid t-butyl ester

생성물 1

HCID 21098553[2-(4-Fluoro-3-methoxyphenyl)ethyl]methylamine hydrochloride

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of [2-(4-fluoro-3-methoxyphenyl)ethyl]methylcarbamic acid t-butyl ester (506 mg) in ethyl acetate (2 mL) was added a solution of 4N hydrochloric acid-ethyl acetate (2 mL) at room temperature and allowed to stand for 2.5 hours. The resulting solid was diluted with diethyl ether, then filtered, and washed with diethyl ether. After drying by aeration, the title compound (338 mg) was obtained as a colorless solid.

후처리

  1. filtrationfiltered
  2. washwashed with diethyl ether
  3. customAfter drying by aeration

출처 및 근거

ORD 기록
ord-6aa24a190bbb48b5a545aa134e129106
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217723B2

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