Potassium Carbonate → (2S)-[2-(4-Fluorophenyl)-2-hydroxyethyl]methylcarbamic acid t-butyl ester

HRID 1351267노트

반응식

HRID 1351267 반응식
[C:1]([O:5][C:6]([N:8]([CH3:30])[CH2:9][C@@H:10]([O:18]C(=O)[C@@H](OC)C1C=CC=CC=1)[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[C:1]([O:5][C:6](=[O:7])[N:8]([CH2:9][C@H:10]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)[OH:18])[CH3:30])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 86600988(2S)-methoxyphenyl acetic acid (1S)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester

생성물 1

HCID 69416829(2S)-[2-(4-Fluorophenyl)-2-hydroxyethyl]methylcarbamic acid t-butyl ester

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of (2S)-methoxyphenyl acetic acid (1S)-2-(t-butoxycarbonyl-methylamino)-1-(4-fluorophenyl)ethyl ester (the compound of Preparation Example 35) (3.6 g) in methanol (17 mL) was added potassium carbonate (1.8 g) on an ice bath. After stirring at room temperature for 30 minutes, the colorless solid that was generated by diluting with water was collected by filtration. After washing with water, and then drying by aeration, the title compound (2.35 g) was obtained as a colorless solid. The NMR data matched the racemic mixture described in Preparation Example 32.

후처리

  1. filtrationwas collected by filtration
  2. washAfter washing with water
  3. customdrying by aeration

출처 및 근거

ORD 기록
ord-22caf8bad319436d96570242f9afbedd
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217723B2

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