7-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride → HCID 69415009, 화합물

HRID 1351277노트

반응식

HRID 1351277 반응식
[O:1]=[C:2]1[C:7]2[S:8][CH:9]=[C:10]([S:11](Cl)(=[O:13])=[O:12])[C:6]=2[CH2:5][CH2:4][CH2:3]1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([C@@H:22]([OH:26])[CH2:23][NH:24][CH3:25])=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:17]=[CH:18][C:19]([C@@H:22]([OH:26])[CH2:23][N:24]([CH3:25])[S:11]([C:10]2[C:6]3[CH2:5][CH2:4][CH2:3][C:2](=[O:1])[C:7]=3[S:8][CH:9]=2)(=[O:13])=[O:12])=[CH:20][CH:21]=1

참가 물질

3

반응물 2

HCID 210986857-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chlorideHCID 42182667HCID 42182667, 화합물

생성물 1

HCID 69415009HCID 69415009, 화합물

실험 절차

From 7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7) (286 mg) and (1R)-1-(4-fluorophenyl)-2-(methylamino)ethanol (the compound of Preparation Example 40) (212 mg), the title compound (356 mg) was obtained as a colorless solid, in the same way as Preparation Example 41. The NMR data matched the racemic mixture described in Preparation Example 48. The optical purity as measured by high performance liquid chromatography (ChiralPak AD-H, hexane:2-propanol=8:2) was >99% e.e.

후처리

  1. customthe compound of Preparation Example 40) (212 mg)

출처 및 근거

ORD 기록
ord-a9f6a6b8299749c08d37ddd3583bc9f4
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217723B2

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