(2-(4-Fluorophenyl)ethyl)(methyl)amine → 6-Methyl-7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonic acid[2-(4-fluorophenyl)ethyl]-methyl-amide

HRID 1351286노트

반응식

HRID 1351286 반응식
[CH3:1][CH:2]1[C:14](=[O:15])[C:6]2[S:7][CH:8]=[C:9]([S:10](Cl)(=[O:12])=[O:11])[C:5]=2[CH2:4][CH2:3]1.[F:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][NH:25][CH3:26])=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][N:25]([CH3:26])[S:10]([C:9]2[C:5]3[CH2:4][CH2:3][CH:2]([CH3:1])[C:14](=[O:15])[C:6]=3[S:7][CH:8]=2)(=[O:12])=[O:11])=[CH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 120234(2-(4-Fluorophenyl)ethyl)(methyl)amineHCID 210986726-Methyl-7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride

생성물 1

HCID 210986706-Methyl-7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonic acid[2-(4-fluorophenyl)ethyl]-methyl-amide

실험 절차

From 6-methyl-7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 13) (140 mg) and [2-(4-fluorophenyl)ethyl]methylamine (the compound of Preparation Example 14) (98 mg), the title compound (152 mg) was obtained as an orange oily substance, in the same way as Preparation Example 41.

후처리

  1. customthe compound of Preparation Example 14) (98 mg)

출처 및 근거

ORD 기록
ord-a71681e5cb1441d9880ce2217c7aaf53
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217723B2

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