(+-)-alpha-Methyl-alpha-phenylsuccinimide → 3-Methyl-3-phenylpyrrolidine

반응식

[CH3:1][C:2]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][C:5](=O)[NH:4][C:3]1=O.[H-].[Li+].[Al+3].[H-].[H-].[H-]>>[CH3:1][C:2]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:5][NH:4][CH2:3]1

참가 물질

반응물 2

HCID 92154(+-)-alpha-Methyl-alpha-phenylsuccinimide

HCID 21226445Aluminium lithium hydride

생성물 1

HCID 210986163-Methyl-3-phenylpyrrolidine

실험 절차

3-Methyl-3-phenyl-pyrrolidine, which was synthesized by reducing 3-methyl-3-phenyl pyrrolidine-2,5-dione with aluminum lithium hydride, was used as the amine to carry out the reaction according to <method α>. A purification by silica gel column chromatography (hexane/ethyl acetate) was carried out, and, the title compound (7 mg) was obtained as a colorless solid.

후처리

customA purification by silica gel column chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록: ord-66286f62f78e4d4ebbd21eb86cd45d7a
출처 데이터셋: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07217723B2

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