Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → tert-Butyl 3-carbamoylmorpholine-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Di-tert-butyl dicarbonate | HCID 90495 | — |
| 반응물 | 4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid | HCID 2760133 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | tert-Butyl 3-carbamoylmorpholine-4-carboxylate | HCID 21098189 | — |
반응 단계
To a stirred solution of the compound prepared in Step 1 (1 eq.), pyridine (0.6 eq.) and di-t-butyl dicarbonate (1.3 eq.) in dioxane (0.6 M), NH4HCO3 (1.26 eq.) was added and the mixture was stirred at room temperature for 20 hours. Mixture was concentrated, taken up in EtOAc and washed with water and brine. Organics were dried over Na2SO4 and evaporated giving the title product as an oil which crystallized at room temperature.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07217713B2 |
| 출처 데이터셋 | uspto-grants-2007_05 |
| ORD ID | ord-f2efb6265014408f8e189eb547b261b0 |
| 출처 메모 | uspto-grants-2007_05 |