Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → tert-Butyl 3-cyanomorpholine-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Trifluoroacetic anhydride | HCID 9845 | — |
| 반응물 | tert-Butyl 3-carbamoylmorpholine-4-carboxylate | HCID 21098189 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-Butyl 3-cyanomorpholine-4-carboxylate | HCID 21098190 | — |
반응 단계
A solution of the product of Step 2 (1 eq.) and triethylamine (2.1 eq.) in CH2Cl2 (0.1 M) was cooled to 0° C. and-trifluoroacetic anhydride (1.1 eq.) added dropwise under nitrogen. Stirring was continued 3.5 hours more at room temperature and volatiles removed in vacuo. Residues taken in EtOAc were washed with water, brine and dried over Na2SO4. Evaporation gave the title compound as a brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07217713B2 |
| 출처 데이터셋 | uspto-grants-2007_05 |
| ORD ID | ord-f3c939e449c645d68dd58527541c32ae |
| 출처 메모 | uspto-grants-2007_05 |