Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | 5-Fluoro-2-nitroaniline | HCID 75399 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-(4-Methylpiperazin-1-yl)-2-nitroaniline | HCID 2760034 | — |
반응 단계
A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728010B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-912e0e0b843a42cba63f5551c1645ee6 |
| 출처 메모 | uspto-grants-2010_06 |