2-Cyclopentyloxy-5-methanesulfonyl-benzoic acid → 2-[4-(2-Cyclopentyloxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-thiazole-5-carbonitrile
반응식
[CH:1]1([O:6][C:7]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][C:8]=2[C:9]([OH:11])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:20]1([C:26]2[S:27][C:28]([C:31]#[N:32])=[CH:29][N:30]=2)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH:1]1([O:6][C:7]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][C:8]=2[C:9]([N:23]2[CH2:24][CH2:25][N:20]([C:26]3[S:27][C:28]([C:31]#[N:32])=[CH:29][N:30]=3)[CH2:21][CH2:22]2)=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5]1참가 물질
3
실험 절차
Prepared in analogy to example 1 (b) from 2-cyclopentyloxy-5-methanesulfonyl-benzoic acid (Example A4) and 2-piperazin-1-yl-thiazole-5-carbonitrile (Example 6(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 64%). MS (m/e): 461.3 (M+H+, 100%).
후처리
- customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)