Diethyl disulfide → 4-(5-Ethylsulfanyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 1352315

반응식

HRID 1352315 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16](Br)=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:20]([S:22]SCC)[CH3:21]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([S:22][CH2:20][CH3:21])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 8077Diethyl disulfideHCID 34180719Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)piperazine-1-carboxylate

생성물 1

HCID 684067764-(5-Ethylsulfanyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester수율 86%

실험 절차

Prepared in analogy to example 4 (b) from 4-(5-bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (Example 4(a)) and diethyl disulphide. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to afford the title compound as a white crystalline solid (yield 86%). MS (m/e): 330.3 (M+H+, 100%).

후처리

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

출처 및 근거

ORD 기록
ord-df82ae43cd314053849c8ae2fa57d49b
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220744B2

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