1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → HCID 21100301, 화합물
반응식
[CH2:1]([S:3]([C:6]1[CH:7]=[CH:8][C:9]([O:15][CH:16]([CH3:18])[CH3:17])=[C:10]([CH:14]=1)[C:11]([OH:13])=O)(=[O:5])=[O:4])[CH3:2].Cl.[F:20][C:21]([F:34])([F:33])[C:22]1[S:26][C:25]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:24][CH:23]=1>>[CH2:1]([S:3]([C:6]1[CH:7]=[CH:8][C:9]([O:15][CH:16]([CH3:18])[CH3:17])=[C:10]([C:11]([N:30]2[CH2:31][CH2:32][N:27]([C:25]3[S:26][C:22]([C:21]([F:34])([F:20])[F:33])=[CH:23][N:24]=3)[CH2:28][CH2:29]2)=[O:13])[CH:14]=1)(=[O:4])=[O:5])[CH3:2]참가 물질
3
실험 절차
Prepared in analogy to example 1 (b) from 5-ethanesulfonyl-2-isopropoxy-benzoic acid (Example A18) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by reversed phase HPLC (acetonitrile/water) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 21%). MS (m/e): 492.1 (M+H+, 100%).
후처리
- customThe crude material was purified by reversed phase HPLC (acetonitrile/water)