1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → HCID 11584029, 화합물

HRID 1352382노트

반응식

HRID 1352382 반응식
[C@H:1]([O:5][C:6]1[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][C:7]=1[C:8]([OH:10])=O)([CH2:3][CH3:4])[CH3:2].Cl.[F:20][C:21]([F:34])([F:33])[C:22]1[S:26][C:25]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:24][CH:23]=1>>[C@H:1]([O:5][C:6]1[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][C:7]=1[C:8]([N:30]1[CH2:31][CH2:32][N:27]([C:25]2[S:26][C:22]([C:21]([F:34])([F:20])[F:33])=[CH:23][N:24]=2)[CH2:28][CH2:29]1)=[O:10])([CH2:3][CH3:4])[CH3:2]

참가 물질

3

반응물 2

HCID 211002001-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochlorideHCID 588633572-((R)-sec-Butoxy)-5-methanesulfonyl-benzoic acid

생성물 1

HCID 11584029HCID 11584029, 화합물수율 10%

실험 절차

Prepared in analogy to example 1 (b) from 2-((R)-sec-butoxy)-5-methanesulfonyl-benzoic acid (Example A20) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by reversed phase HPLC (acetonitrile/water) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 10%). MS (m/e): 492.4 (M+H+, 100%).

후처리

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)

출처 및 근거

ORD 기록
ord-13ab370191374c65a98b7014b2c23e9b
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220744B2

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