N,N-Diethyl-2,3-dimethylbenzamide → 3-[2-(3-hydroxypiperidin-1-yl)ethyl]-2H-isoquinolin-1-one

HRID 1352445노트

반응식

HRID 1352445 반응식
C([N:3]([CH2:14][CH3:15])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7](C)[C:6]=1[CH3:12])C.[OH:16][CH:17]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:23]CC#N)[CH2:18]1>>[OH:16][CH:17]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:23][CH2:15][C:14]2[NH:3][C:4](=[O:13])[C:5]3[C:6]([CH:12]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH2:18]1

참가 물질

3

반응물 2

HCID 15621069N,N-Diethyl-2,3-dimethylbenzamideHCID 230820923-(3-Hydroxypiperidin-1-yl)propionitrile

생성물 1

HCID 100846303-[2-(3-hydroxypiperidin-1-yl)ethyl]-2H-isoquinolin-1-one수율 19.2%

실험 절차

By the reaction in the same manner as in Example 1a, using N,N-diethyl-2,3-dimethylbenzamide (5.2474 g) and 3-(3-hydroxypiperidin-1-yl)propionitrile (2.62 g), 3-[2-(3-hydroxypiperidin-1-yl)ethyl]-2H-isoquinolin-1-one (888.2 mg) was obtained.

후처리

  1. customBy the reaction in the same manner as in Example 1a

출처 및 근거

ORD 기록
ord-a41d34a63467487f91ab44ed5ed7e57a
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220759B2

반응 노트

불러오는 중…