2-Bromoethanol → HCID 10445940, 화합물

반응식

Cl.[CH3:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([CH:14]1[CH2:18][CH2:17][NH:16][CH2:15]1)[NH:7][C:8]2=[O:13].Br[CH2:20][CH2:21][OH:22]>>[OH:22][CH2:21][CH2:20][N:16]1[CH2:17][CH2:18][CH:14]([C:6]2[NH:7][C:8](=[O:13])[C:9]3[C:4]([CH:5]=2)=[C:3]([CH3:2])[CH:12]=[CH:11][CH:10]=3)[CH2:15]1

참가 물질

반응물 2

HCID 108982-Bromoethanol

HCID 22931207HCID 22931207, 화합물

생성물 1

HCID 10445940HCID 10445940, 화합물

실험 절차

By the reaction in the same manner as in Example 2a, using 5-methyl-3-(pyrrolidin-3-yl)-2H-isoquinolin-1-one hydrochloride (200 mg) and 2-bromoethanol (270 μl), 3-[1-(2-hydroxyethyl)pyrrolidin-3-yl]-5-methyl-2H-isoquinolin-1-one (39 mg) was obtained.

후처리

customBy the reaction in the same manner as in Example 2a

출처 및 근거

ORD 기록: ord-fe7a76e110644afd9f19edb8c8918812
출처 데이터셋: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07220759B2

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