Acrylonitrile → HCID 68644380, 화합물

HRID 1352470노트

반응식

HRID 1352470 반응식
Cl.[OH:2][CH2:3][C@@H:4]1[NH:8][CH2:7][C@@H:6]([OH:9])[CH2:5]1.[C:10](#[N:13])[CH:11]=[CH2:12]>C(=O)([O-])[O-].[K+].[K+].C(#N)C>[OH:9][C@@H:6]1[CH2:7][N:8]([CH2:12][CH2:11][C:10]#[N:13])[C@@H:4]([CH2:3][OH:2])[CH2:5]1

참가 물질

5

반응물 2

HCID 7855AcrylonitrileHCID 68644206(3S,5R)-5-(HYDROXYMETHYL)PYRROLIDIN-3-OL HCL

생성물 1

HCID 68644380HCID 68644380, 화합물

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 11430Potassium Carbonate용매

실험 절차

(3S,5R)-5-Hydroxymethylpyrrolidin-3-ol hydrochloride (0.4 g) described in Biochemistry, Vol. 5, pp. 1154–1155 (1966) was dissolved in aqueous potassium carbonate solution (2 mL) and acetonitrile (2 mL). Acrylonitrile (0.5 mL) was added and the mixture was stirred at room temperature for 5 hr. After the completion of the reaction, the reaction mixture was concentrated and the obtained residue was suspended in chloroform-methanol and dried by adding magnesium sulfate. Magnesium sulfate was filtered off and the solvent was concentrated to give 3-[(2R,4S)-4-hydroxy-2-hydroxymethylpyrrolidin-1-yl]propionitrile (0.47 g).

후처리

  1. customAfter the completion of the reaction
  2. concentrationthe reaction mixture was concentrated
  3. customdried
  4. additionby adding magnesium sulfate
  5. filtrationMagnesium sulfate was filtered off
  6. concentrationthe solvent was concentrated

출처 및 근거

ORD 기록
ord-2244a8fe2aae448c800eb04f3cc90039
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220759B2

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