4-Chloroquinoline → 4-Methoxyquinoline

HRID 1352484

반응식

HRID 1352484 반응식
[CH3:1][O-:2].[Na+].Cl[C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][CH:6]=1>CO>[CH3:1][O:2][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 691404-ChloroquinolineHCID 10942334Sodium Methoxide

생성물 1

HCID 5219384-Methoxyquinoline수율 76%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of sodium methoxide (33 g) in methanol (130 ml), 4-chloroquinoline (10 g) was added under stirring. The mixture was heated under reflux for 6 hours. After cooling, the reaction mixture was concentrated, then dissolved in dichloromethane (250 ml) and washed with water (250 ml). The organic layer was dried over sodium sulfate. The solvent was evaporated to give a yellow oil (7.39 g, 76% yield) which was not purified.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 6 hours
  3. temperatureAfter cooling
  4. concentrationthe reaction mixture was concentrated
  5. dissolutiondissolved in dichloromethane (250 ml)
  6. washwashed with water (250 ml)
  7. dry with materialThe organic layer was dried over sodium sulfate
  8. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-bec4131bde0f43f59b57d4718ce90a6c
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220760B2

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