Trifluoroacetic acid → HCID 21100737, 화합물

HRID 1352513노트

반응식

HRID 1352513 반응식
FC(F)(F)C(O)=O.C(OC(=O)[NH:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[C:25]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:24][O:23][N:22]=2)=[CH:17][CH:16]=1)(C)(C)C>>[CH2:26]([C:25]1[C:21]([C:18]2[CH:17]=[CH:16][C:15]([NH2:14])=[CH:20][CH:19]=2)=[N:22][O:23][CH:24]=1)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 69422093HCID 69422093, 화합물

생성물 1

HCID 21100737HCID 21100737, 화합물수율 70%

실험 절차

Trifluoroacetic acid (0.5 mL) is added to [4-(4-benzylisoxazol-3-yl)phenyl]carbamic acid tert-butyl ester (0.3 g) and stirred for 30 minutes. The reaction mixture is concentrated under reduced pressure and the concentrate is partitioned between ethyl acetate and 1N sodium hydroxide solution. The organic layer is washed with saturated sodium chloride, dried over anhydrous magnesium sulfate and chromatographed on silica gel (ethyl acetate/hexane as eluant) to give 0.15 g product as a white solid. MS: m/z 251 (M+H)+.

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customthe concentrate is partitioned between ethyl acetate and 1N sodium hydroxide solution
  3. washThe organic layer is washed with saturated sodium chloride
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customchromatographed on silica gel (ethyl acetate/hexane as eluant)

출처 및 근거

ORD 기록
ord-c517227dcce74e24ba87c98372128d96
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220768B2

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