Thionyl Chloride → 4-Cyano-2-ethoxybenzoyl chloride

HRID 1352658노트

반응식

HRID 1352658 반응식
[CH2:1]([O:3][C:4]1[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][C:5]=1[C:6](O)=[O:7])[CH3:2].S(Cl)([Cl:17])=O>C(Cl)Cl>[CH2:1]([O:3][C:4]1[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][C:5]=1[C:6]([Cl:17])=[O:7])[CH3:2]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 226750384-Cyano-2-ethoxybenzoic acid

생성물 1

HCID 211007434-Cyano-2-ethoxybenzoyl chloride수율 99%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Ethoxy-4-cyanobenzoic acid (10 g, 52.3 mmol), prepared as in Preparation 10, and thionyl chloride (50 ml,) were refluxed in CH2Cl2 (80 ml) for 5 h. Solvent was removed under vacuum to leave 10.9 g of an off white solid (52 mmol, yield 99%) that was used without further purification.

후처리

  1. customSolvent was removed under vacuum

출처 및 근거

ORD 기록
ord-157a517639664487bcb1527f2d671db2
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220769B2

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