Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | Ethyl 2-(formylamino)-alpha-oxo-4-thiazoleacetate | HCID 2733245 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate | HCID 14326717 | — |
반응 단계
Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate (9.1 g, 39.87 mmol) (obtained from Aldrich, Milwaukee, Wis.) was slurried in 50 mL of anhydrous DMF. N-Chlorosuccinimide (5.6 g, 41.86 mmol) was added as a solid and the suspension was stirred at room temperature. After 18 hours, the reaction mixture was poured into 500 mL of water. The resulting white precipitate was filtered, washed with water and air dried to afford the title intermediate as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728127B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-572aaac4a1614a098cd42dd318d131d2 |
| 출처 메모 | uspto-grants-2010_06 |