Trifluoroacetic acid → (2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

HRID 1353206

반응식

HRID 1353206 반응식
[CH2:1]([O:3][C:4](=[O:24])[C@@H:5]([O:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])=[CH:9][CH:8]=1)[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH2:1]([O:3][C:4](=[O:24])[C@@H:5]([O:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:9][CH:8]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 58864672(2S)-3-(4-tert-butoxycarbonylmethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

생성물 1

HCID 58864673(2S)-3-(4-carboxymethoxy-phenyl)-2-methoxy-propionic acid ethyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The compound of (2S)-3-(4-tert-butoxycarbonylmethoxy-phenyl)-2-methoxy-propionic acid ethyl ester (PREPARATION 3, step 1) (1.2 gr, 3.5 mmol) was solved in dichloromethane (5 ml) and trifluoroacetic acid was added (5 ml). The mixture was stirred for an hour, and the crude was concentrated to afford a yellow oil. 1H-NMR (CDCl3, 200.15 MHz): 7.16 (d, 2H, J=8.3), 6.75 (d, 2H, J=8.3), 4.89 (s, 2H), 4.14 (c, 2H, J=6.9), 3.94 (t, 1H, J=6.9), 3.57 (dc, 1H), 3.35 (dc, 1H), 2.92 (d, 2H, J=6.9), 1.23-1.10 (2t, 6H).

후처리

  1. concentrationthe crude was concentrated
  2. customto afford a yellow oil

출처 및 근거

ORD 기록
ord-222c882ec02b41f2b048d8883f0c32e5
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220880B2

연결된 노트

불러오는 중…