Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
7-Chloro-4-(piperazin-1-yl)quinoline → 7-Chloro-4-[4-(3,4-difluorophenylaminocarbonyl)piperazin-1-yl]quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| 반응물 | 3,4-Difluorophenyl isocyanate | HCID 2734708 | — |
| 반응물 | Ethyl acetate hexane | HCID 21226206 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 7-Chloro-4-[4-(3,4-difluorophenylaminocarbonyl)piperazin-1-yl]quinoline | HCID 21101762 | — |
반응 단계
7-Chloro-4-(piperazin-1-yl)quinoline (0.16 g, 0.65 mmol) and 3,4-difluorophenyl isocyanate (76 μL, 0.65 mmol) in THF (10 mL) are reacted according to method C yielding the title product as a colorless foam after column chromatography with hexane-EtOAc.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07220856B2 |
| 출처 데이터셋 | uspto-grants-2007_05 |
| ORD ID | ord-002734f2b38147448f485034a9f8a25a |
| 출처 메모 | uspto-grants-2007_05 |