2-Tolyl isocyanate → 7-Chloro-4-[4-(2-methylphenylaminocarbonyl)piperazin-1-yl]quinoline

HRID 1353364

반응식

HRID 1353364 반응식
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:18]1([CH3:27])[C:19]([N:24]=[C:25]=[O:26])=[CH:20][CH:21]=[CH:22][CH:23]=1>C(Cl)Cl>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:25]([NH:24][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=4[CH3:27])=[O:26])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 691942-Tolyl isocyanateHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

생성물 1

HCID 211017597-Chloro-4-[4-(2-methylphenylaminocarbonyl)piperazin-1-yl]quinoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

7-Chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) and o-tolyl isocyanate (31 μL, 0.25 mmol) in CH2Cl2 (5 mL) are reacted according to method C yielding the title product as colorless solid.

출처 및 근거

ORD 기록
ord-6257209c864f419aa4535fbde737e486
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220856B2

연결된 노트

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