Triethylamine → 7-Chloro-4-[4-(1,2,3,4-tetrahydronaphth-1-ylaminocarbonyl)piperazin-1-yl]quinoline

HRID 1353376

반응식

HRID 1353376 반응식
[CH:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.Cl[C:13](OC1C=CC([N+]([O-])=O)=CC=1)=[O:14].C(N(CC)CC)C.[Cl:32][C:33]1[CH:42]=[C:41]2[C:36]([C:37]([N:43]3[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]3)=[CH:38][CH:39]=[N:40]2)=[CH:35][CH:34]=1>>[Cl:32][C:33]1[CH:42]=[C:41]2[C:36]([C:37]([N:43]3[CH2:48][CH2:47][N:46]([C:13]([NH:11][CH:1]4[C:10]5[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=5)[CH2:4][CH2:3][CH2:2]4)=[O:14])[CH2:45][CH2:44]3)=[CH:38][CH:39]=[N:40]2)=[CH:35][CH:34]=1

참가 물질

5

반응물 4

HCID 8471TriethylamineHCID 180661,2,3,4-Tetrahydro-1-naphthylamineHCID 821294-Nitrophenyl chloroformateHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

생성물 1

HCID 211017517-Chloro-4-[4-(1,2,3,4-tetrahydronaphth-1-ylaminocarbonyl)piperazin-1-yl]quinoline

실험 절차

1,2,3,4-Tetrahydronaphthylamine (36 μL, 0.25 mmol), 4-nitrophenyl chloroformate (51 mg, 0.25 mmol), triethylamine (140 μL, 1.0 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) are treated according to method D delivering the title product as a colorless oil after column chromatography with hexane-EtOAc.

출처 및 근거

ORD 기록
ord-3d3d41ad5ea44df280e3a1ac65b878cb
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220856B2

연결된 노트

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