Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylcyclohexylamine → 7-Chloro-4-[4-[(4-methylcyclohexyl)aminocarbonyl]piperazin-1-yl]quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylcyclohexylamine | HCID 80604 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| 반응물 | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 7-Chloro-4-[4-[(4-methylcyclohexyl)aminocarbonyl]piperazin-1-yl]quinoline | HCID 21101730 | — |
반응 단계
As described for example 78, 4-methylcyclohexylamine (206.1 mg, 1.82 mmol), 4-nitrophenyl chloroformate (366 mg, 1.82 mmol), diisopropyl(ethyl)amine (554 mg, 4.3 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (300 mg, 1.21 mmol) are reacted affording the title product after flash chromatography with CH2Cl2-MeOH.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07220856B2 |
| 출처 데이터셋 | uspto-grants-2007_05 |
| ORD ID | ord-90e7e55c012340a89f5ffca740f1d2f0 |
| 출처 메모 | uspto-grants-2007_05 |