Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-(4-Formylbenzoyl)-4-isopropylpiperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 1-Isopropylpiperazine | HCID 78013 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 4-Formylbenzoyl chloride | HCID 12424620 | — |
| 생성물 | 1-(4-Formylbenzoyl)-4-isopropylpiperazine | HCID 57478581 | — |
반응 단계
A solution of 4-formyl-benzoyl chloride (2.80, 16.65 mol) (prepared as in Example 1 above) in toluene (43.3 g, 469.39 mmol) was added slowly to a solution of NaHCO3 (0.8 g, 9.52 mmol) and 4-isopropylpiperazine (2.50 g, 18.35 mmol) in water (5 g, 277 mmol) at 0° C. The reaction mixture was vigorously stirred until the reaction was deemed complete. The layers were split and the toluene phase was concentrated to yield the title compound as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728129B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-12c0f95a39454b7eb5c209df9b63506f |
| 출처 메모 | uspto-grants-2010_06 |