Hydrazine → Piracetam hydrazide

HRID 1353887

반응식

HRID 1353887 반응식
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]C)=O.[NH2:12][NH2:13]>C(O)C>[NH2:12][NH:13][C:8](=[O:10])[CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 108835Methyl 2-oxo-1-pyrrolidineacetate

생성물 1

HCID 3565593Piracetam hydrazide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of methyl 2-(2-oxopyrrolidinyl)acetate (0.884 mL, 6.36 mmol) in 1 mL of anhydrous ethanol was added anhydrous hydrazine (0.308 mL, 6.36 mmol). The solution was heated to reflux temperature overnight. The solvent was then removed under reduced pressure and the product was isolated as a solid in a quantitative yield and was used without further purification: 1H NMR (CDCl3) δ 8.17 (br s, 1H), 3.94 (s, 2H), 3.55 (t, 2H), 2.43 (t, 2H), 2.10 (quintet, 2H); ES-MS (m/z) 158 [M+H]+.

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux temperature overnight
  3. customThe solvent was then removed under reduced pressure
  4. customthe product was isolated as a solid in a quantitative yield
  5. customwas used without further purification

출처 및 근거

ORD 기록
ord-81e1c2e895cf42f6ad52314f673d7a0d
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220771B2

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