Sulfuric Acid → 5-(2-Bromopyrid-5-yl)-1-azabicyclo[3.2.1]oct-3-ene
반응식
O[C:2]1([C:10]2[CH:11]=[CH:12][C:13]([Br:16])=[N:14][CH:15]=2)[CH:7]2[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]2)[CH2:3]1.S(=O)(=O)(O)O>>[Br:16][C:13]1[CH:12]=[CH:11][C:10]([C:2]23[CH2:3][N:4]([CH2:5][CH2:6]2)[CH2:9][CH:8]=[CH:7]3)=[CH:15][N:14]=1참가 물질
3
반응 조건
- 온도
- 190 °C
실험 절차
9.4 g (0.033 mol) of 3-hydroxy-3-(2-bromopyridin-5-yl)-l-azabicyclo[2.2.2]octane and 35 ml of concentrated sulphuric acid are introduced into a 100 ml three-necked flask and the mixture is heated at 190° C. for 1 h 45.
출처 및 근거
- ORD 기록
- ord-fe932df078d34303bc9dd4f9fe7eae12
- 출처 데이터셋
- uspto-grants-2007_05
- 특허 번호
- US07223750B2
반응 노트
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