6-(4-Nitrobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine → 6-(4-Aminobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

HRID 1354

반응식

HRID 1354 반응식
[N+:1]([C:4]1[CH:27]=[CH:26][C:7]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[C:14]3[N:21]=[C:22]([CH3:25])[N:23]([CH3:24])[C:13]=3[CH2:12][CH2:11]2)=[O:9])=[CH:6][CH:5]=1)([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:27]=[CH:26][C:7]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[C:14]3[N:21]=[C:22]([CH3:25])[N:23]([CH3:24])[C:13]=3[CH2:12][CH2:11]2)=[O:9])=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 699555616-(4-Nitrobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

생성물 1

HCID 699556416-(4-Aminobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A 1.421 g portion of 6-(4-nitrobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine was dissolved in 50 ml of methyl alcohol, and the solution was mixed with 300 mg of palladium-carbon and subjected to hydrogenation under normal pressure. After completion of the hydrogen absorption, the reaction mixture was subjected to filtration and the resulting filtrate was concentrated to obtain 571 mg of 6-(4-aminobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine.

후처리

  1. customAfter completion of the hydrogen absorption
  2. filtrationthe reaction mixture was subjected to filtration
  3. concentrationthe resulting filtrate was concentrated

출처 및 근거

ORD 기록
ord-b911c15a1a684981b9d7562f530a2f04
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723606

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