Ethanol → [2-(6-Methoxy-quinazolin-4-yl)-ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

HRID 1354206노트

반응식

HRID 1354206 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][N:7]=[C:6]2[C:13]#[C:14][C:15]1([OH:25])[CH2:24]CC2(OCCO2)CC1.[CH3:26][CH2:27][OH:28]>C1COCC1.[Pt]=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][N:7]=[C:6]2[CH2:13][CH2:14][CH:15]1[CH2:24][O:28][C:27]2([CH2:11][CH2:12][CH:3]([OH:2])[CH2:4][CH2:26]2)[O:25]1

참가 물질

5

반응물 2

HCID 702EthanolHCID 211046688-(6-Methoxy-quinazolin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-ol

생성물 1

HCID 86603231[2-(6-Methoxy-quinazolin-4-yl)-ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 8028Tetrahydrofuran용매

실험 절차

Platinum oxide (0.46 g) was added to a solution of 8-(6-methoxy-quinazolin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-ol (0.96 g, 2.88 mmol) in EtOH (40 ml) and THF (10 ml), and hydrogenation was carried out under a hydrogen atmosphere (1 bar). The reaction mixture was stirred in the presence of activated carbon (5 g) and filtered. The filtrate was concentrated to dryness by rotary evaporation. The residue was purified by column chromatography on silica gel (EtOAc and then EtOAc:MeOH 9/1).

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated to dryness by rotary evaporation
  3. customThe residue was purified by column chromatography on silica gel (EtOAc

출처 및 근거

ORD 기록
ord-5d443ac33af84a09a6b4388cf7724908
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223776B2

반응 노트

불러오는 중…