참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Formylbenzoic acid | HCID 12088 | — |
| 반응물 | Chloro-N,N-dimethylformiminium chloride | HCID 77311 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Formylbenzoyl chloride | HCID 12424620 | — |
반응 단계
A suspension of (chloromethylene)dimethylammonium chloride (Vilsmeier Reagent; 37.7 g, 0.280 mol) in CH2Cl2 (300 mL) at 0° C. was treated with 4-carboxybenzaldehyde (40.0 g, 267 mmol) in one portion. The reaction mixture was stirred at 0° C. for 30 min, then at room temperature for 2 h. HPLC analysis of an aliquot of the reaction mixture quenched into MeOH indicated consumption of 4-carboxybenzaldehyde. The reaction mixture was filtered through a medium porosity glass frit. The filtrate, containing the title compound, was stored at 0° C., and used in the next step without further manipulation.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728129B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-a6cfdb8f7041403d96a62694f8d57739 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
