tert-Butyl (2,3-dihydroxypropyl)methylcarbamate → tert-butyl N-methyl-N-(2-oxoethyl)carbamate

HRID 1354525노트

반응식

HRID 1354525 반응식
[C:1]([N:8]([CH3:14])[CH2:9][CH:10]([OH:13])CO)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>O>[C:1]([N:8]([CH3:14])[CH2:9][CH:10]=[O:13])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

참가 물질

3

반응물 1

HCID 17878865tert-Butyl (2,3-dihydroxypropyl)methylcarbamate

생성물 1

HCID 10725881tert-butyl N-methyl-N-(2-oxoethyl)carbamate수율 79%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of N-Boc-N-methyl-1-amino-2,3-propandiol (20g, 0.097 mol) in water (100 ml) was added KIO4 (24.68g, 0.108 mol). The reaction mixture was stirred for 2.5 hr under an atmosphere of nitrogen and then filtered. The filtrate was extracted with chloroform (5×50 ml). The resulting chloroform extracts are dried over MgSO4, filtered, and evaporated to dryness. The title compound 13.26g (79%) was isolated as a clear oil (bp 76-80° C. at 0.5 mm Hg).

후처리

  1. filtrationfiltered
  2. extractionThe filtrate was extracted with chloroform (5×50 ml)
  3. dry with materialThe resulting chloroform extracts are dried over MgSO4
  4. filtrationfiltered
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-bdb416062209445ab264f217412f1bea
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223833B1

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