4,6-Dichloro-5-pyrimidinecarbaldehyde → 2-(4,6-Dichloro-pyrimidin-5-yl)-6-imidazol-1-yl-4-methyl-1H-benzimidazole

HRID 1354619노트

반응식

HRID 1354619 반응식
[N:1]1([C:6]2[CH:11]=[C:10]([NH2:12])[C:9]([NH2:13])=[C:8]([CH3:14])[CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[Cl:15][C:16]1[C:21]([CH:22]=O)=[C:20]([Cl:24])[N:19]=[CH:18][N:17]=1>CO>[Cl:15][C:16]1[C:21]([C:22]2[NH:12][C:10]3[CH:11]=[C:6]([N:1]4[CH:5]=[CH:4][N:3]=[CH:2]4)[CH:7]=[C:8]([CH3:14])[C:9]=3[N:13]=2)=[C:20]([Cl:24])[N:19]=[CH:18][N:17]=1

참가 물질

4

반응물 2

HCID 8196914,6-Dichloro-5-pyrimidinecarbaldehydeHCID 104199825-Imidazol-1-yl-3-methyl-benzene-1,2-diamine

생성물 1

HCID 220211832-(4,6-Dichloro-pyrimidin-5-yl)-6-imidazol-1-yl-4-methyl-1H-benzimidazole수율 55%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of 5-imidazol-1-yl-3-methyl-benzene-1,2-diamine (180 mg, 0.96 mmol) in methanol (4 mL) was added a solution of 4,6-dichloro-pyrimidine-5-carbaldehyde (183 mg, 0.96 mmol) in methanol (1 mL). The reaction mixture was stirred at room temperature for 14 h. After concentration, the residue was purified by flash column chromatography (5% methanol/CH2Cl2) to yield the title compound (180 mg, 55%). LCMS (M+H)+ m/z 344 (t=1.31 min.).

후처리

  1. concentrationAfter concentration
  2. customthe residue was purified by flash column chromatography (5% methanol/CH2Cl2)

출처 및 근거

ORD 기록
ord-6e62499817dc459cb9aba6780205af28
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223757B2

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