Trifluoroacetic acid → (R)-methyl-[1-(4-nitrophenyl)pyrrolidin-3-yl]amine

HRID 1354671노트

반응식

HRID 1354671 반응식
[CH3:1][N:2]([C@@H:10]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)[CH2:11]1)C(=O)OC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:1][NH:2][C@@H:10]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)[CH2:11]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67148139tert-Butyl (R)-methyl-[1-(4-nitrophenyl)pyrrolidin-3-yl]carbamate

생성물 1

HCID 67147986(R)-methyl-[1-(4-nitrophenyl)pyrrolidin-3-yl]amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of tert-butyl (R)-methyl-[1-(4-nitrophenyl)pyrrolidin-3-yl]-carbamate (0.7 g) in dichloromethane (5 ml) was treated with trifluoroacetic acid (3 ml) for 1 hour. The reaction solution was concentrated and the residue was taken up in dichloromethane. After washing with sodium carbonate solution, the organic phase was dried over magnesium sulfate and concentrated. This resulted in the product with the molecular weight of 221.26 (C11H15N3O2); MS (ESI): 222 (M+H+).

후처리

  1. concentrationThe reaction solution was concentrated
  2. washAfter washing with sodium carbonate solution
  3. dry with materialthe organic phase was dried over magnesium sulfate
  4. concentrationconcentrated
  5. customThis resulted in the product with the molecular weight of 221.26 (C11H15N3O2)

출처 및 근거

ORD 기록
ord-41a16afa3abf4b61b8c86a94252861c5
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223788B2

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