Cyanuric chloride → HCID 21103674, 화합물

HRID 1354818노트

반응식

HRID 1354818 반응식
C([O-])(O)=O.[Na+].[NH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:37])[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:17][C:16]=2[O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[C:9]([OH:38])[CH:8]=1.[N:39]1[C:46]([Cl:47])=[N:45][C:43](Cl)=[N:42][C:40]=1[Cl:41]>C1COCC1>[CH2:30]([O:29][C:16]1[CH:17]=[C:18]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:19]=[CH:20][C:15]=1[C:14]([NH:13][C:10]1[CH:11]=[CH:12][C:7]([NH:6][C:43]2[N:45]=[C:46]([Cl:47])[N:39]=[C:40]([Cl:41])[N:42]=2)=[CH:8][C:9]=1[OH:38])=[O:37])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

참가 물질

5

반응물 3

HCID 7954Cyanuric chlorideHCID 516892Sodium BicarbonateHCID 21104165HCID 21104165, 화합물

생성물 1

HCID 21103674HCID 21103674, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

NaHCO3 (300 mg, 3.58 mmol) was added to a solution of compound 40 (263.8 mg, 598 μmol) in THF (5 mL). Cyanuric chloride (110 mg, 598 μmol) in THF (3 mL) was added to the reaction mixture in an ice water bath. The reaction mixture was stirred from 0° C. to room temperature for 30 minutes. The reaction progress was monitored by TLC and LC-MS. The reaction mixture was directly used in the next step. LC-MS (ESI): m/e=588.2 [M+H]+

출처 및 근거

ORD 기록
ord-9dd38979835c4da98e880d8e2dbd0342
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223759B2

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