3-(4-Benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester → Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate

HRID 1354888

반응식

HRID 1354888 반응식
[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17]CC2C=CC=CC=2)=[CH:13][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:2].[H][H]>[Pd].S1CCOCC1>[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:2]

참가 물질

5

반응물 2

HCID 110779683-(4-Benzyloxyphenyl)-2-ethoxypropanoic acid ethyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 11791243Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate수율 97%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 275961,4-Oxathiane용매

실험 절차

A mixture of racemic ethyl 2oxy-3-(4-benzyloxyphenyl)propionate of the formula (12a) (40 g) obtained according to the procedure described in step (iv) above, 5% Pd/C catalyst (8 g) and 1,4-thioxane (200 ml) was subjected to hydrogenation at room temperature and 50–60 psi of hydrogen pressure for a period of 8–12 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the catalyst was filtered off and the solvent was removed under reduced pressure to afford the title compound of the formula (13a) (28–29 g, 97–98%).,

후처리

  1. customobtained
  2. customwas subjected to hydrogenation at room temperature
  3. customAfter completion of the reaction
  4. filtrationthe catalyst was filtered off
  5. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-b8e5f116950147cf9a865c6a834c27c4
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223881B2

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