Triethylamine → 3-Chloro-1-((4-fluorophenyl)amino)-4-phenylpyrrol-2,5-dione

HRID 1355334노트

반응식

HRID 1355334 반응식
[Cl:1][C:2]1[C:3](=[O:14])O[C:5](=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.Cl.[F:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][NH2:24])=[CH:19][CH:18]=1.C(N(CC)CC)C>C(Cl)Cl>[Cl:1][C:2]1[C:3](=[O:14])[N:24]([NH:23][C:20]2[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=2)[C:5](=[O:13])[C:6]=1[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 699814-Fluorophenylhydrazine hydrochlorideHCID 234471953-Chloro-4-phenylfuran-2,5-dione

생성물 1

HCID 234471963-Chloro-1-((4-fluorophenyl)amino)-4-phenylpyrrol-2,5-dione

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

3.13 g (15 mmol) of 3-chloro-4-phenylfuran-2,5-dione and 2.44 g (15 mmol) of 4-fluorophenylhydrazine hydrochloride were initially charged in 50 ml of methylene chloride, and the mixture was, at room temperature, admixed dropwise with stirring with 1.52 g (15 mmol) of triethylamine and stirred at room temperature overnight. A further 50 ml of methylene chloride were added, and the mixture was washed three times with in each case 80 ml of water, dried over sodium sulfate and concentrated under reduced pressure. Yield: 3.9 g of a crystalline solid, m.p. 115-117° C.

후처리

  1. customwas, at room temperature
  2. washthe mixture was washed three times with in each case 80 ml of water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7ae6ee306fb642b483dc236143e3c418
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586369B1

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